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The dozens of types of allergy medication found at your local pharmacy can be overwhelming, but fear not.Second-generation over-the-counter medications like Claritin, Zyrtec, and Allegra — which improve upon old options like Benadryl by not putting you to sleep — are more similar than they are different.In 2014 antihistamines such as desloratadine were found to be effective as adjuvants to standardized treatment of acne due to their anti-inflammatory properties and their ability to suppress sebum production.receptor and heightens the receptor's activity; the receptor antagonists work by binding to the receptor and blocking the activation of the receptor by histamine; by comparison, the inverse agonists bind to the receptor and reduce its activity, an effect which is opposite to histamine's.-antihistamines can also reduce inflammation, since the expression of NF-κB, the transcription factor the regulates inflammatory processes, is promoted by both the receptor's constitutive activity and agonist (i.e., histamine) binding at the H Second-generation antihistamines cross the blood–brain barrier to a much lower degree than the first-generation antihistamines.(There are other types of antihistamines that affect H-2, H-3, and H-4 receptors.) People build up tolerance to them over time and when they stop taking them experience rebound insomnia.Also called histamine antagonists, antihistamines are administered to fight allergic reactions, in which cases sleepiness is considered a possibly undesirable side effect.Among the most popular over-the-counter (OTC) allergy meds are Zyrtec and Claritin.
However, high doses can still induce the central nervous system drowsiness.
Zyrtec and Claritin have very few side effects and are generally recognized as safe for most people. Zyrtec can cause sleepiness, but only in some people.
Take it for the first time when you will be at home for a few hours in case it makes you sleepy.
For people who need to get to sleep, however, the drowsiness is the main benefit of antihistamines.
These are usually not prescription drugs and can be purchased at retailers over-the-counter.