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Calorie restriction (CR), a dietary regimen in which subjects (typically test animals) receive a reduced energy diet (typically, a 20 to 40% reduction in total energy intake relative to an unrestricted comparison group), is one of the most potent and broadly acting dietary interventions for preventing or reversing weight gain and inhibiting cancer in experimental tumor models[], suggest that the beneficial effects of CR on metabolism and chronic disease risk observed in rodent models may extend to human beings.

Observational epidemiologic studies provide additional evidence that CR exerts beneficial effects on longevity and cancer risk in human beings[].

The reaction to the silicone implant is highly variable; it can lead to local inflammatory symptoms, and sometimes to systemic symptoms and disease.

PML# regulates neuroprotective innate immunity and neuroblast commitment in a hypoxia ischemic encephalopathy model. Micro RNA-140 inhibits inflammation and stimulates chondrogenesis in a model of IL1β-induced osteoarthritis.

Aae TF, Randsborg PH, Breen AB, Visnes H, Vindfeld S, Sivertsen EA, Lken S, Brinchmann J, Hanvold HA, ren A. Focal cartilage defects in the knee - a randomized controlled trial comparing autologous chondrocyte implantation with arthroscopic debridement.

Jalland C, Scheffler K, Benestad S, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjrs M, Tranulis M. Behnan J, Stangeland B, Hosainey SA, Joel M, Olsen TK, Micci F, Glover JC, Isakson P, Brinchmann JE. Norwegican Cartilage Project - a study protocol for a double-blinded randomized controlled trial comparing arthroscopic microfracture with arthroscopic debridement in focal cartilage defects in the knee.

Neil3 induced neurogenesis protects against prion disease during the clinical phase. 844Dahl JA, Jung I, Aanes H, Greggains GD, Mana A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjrs M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A. Behnan J, Stangeland B, Langella T, Finocchiaro G, Murrell W, Brinchmann JE. Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency.

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